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Updated: Jan 9, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
Strategies for the Development of NK Cell-Based Therapies for Cancer Treatment
Tatiana Budagova1, Anna Efremova1, Margarita Maiak1
1Federal State Budgetary Scientific Institution Research Centre for Medical Genetics, Moskvorechye Str. 1, Moscow 115522, Russia.
None:
CAR-T cell therapy is a promising method of cancer treatment, but it has some disadvantages. These disadvantages have led scientists to explore the use of safer CAR-NK cells and new genetic modifications in order to improve the effectiveness of CAR cells. In this paper, we analyze existing approaches to modifying CAR-NK cells and discuss the results of clinical trials involving CAR-NK therapies. Conventionally, approaches to NK cell modification can be divided into three main groups: strategies to enhance antitumor cytotoxicity, strategies to improve the survival of CAR-NK cells and prolong their persistence in the body, and strategies to increase the safety of CAR-NK cells. The effects of CAR-NK cells on different tumor types are presented, and the number of clinical trials involving CAR-NK cells has been increasing every year, with positive results so far. As of September 2025, all the trials are in the early 1-2 stages of research, and it is expected that the first CAR-NK product will be approved in the near future.
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