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Updated: Jun 24, 2026
Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
Protective strategies and therapeutic interventions for ischemia-reperfusion injury: potential applications in
Qingze Meng1,2,3, Jiahao Li1,2,3, Jitian He1,2,3
1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Abstract:
Recent advances in perfusion technology have positioned normothermic machine perfusion (NMP) as a promising alternative. However, the unavoidable occurrence of ischemia-reperfusion injury (IRI) during perfusion remains a critical barrier to enhancing postoperative outcomes and graft survival. This review systematically examines current pharmacological strategies to mitigate IRI in NMP, targeting key pathological mechanisms including oxidative stress, inflammatory cascades, apoptotic pathways, and endothelial dysfunction. We highlight promising therapeutic agents that have demonstrated efficacy in animal models, preclinical experiments, and ex vivo human liver studies. In addition, we discuss the current challenges in clinical translation and future development directions.
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