Emerging role of PANoptosis in pathogen infection and systemic diseases

Area of Science:

• Immunology
• Cell Biology
• Pathology

Background:

• PANoptosis is a newly identified programmed cell death pathway.
• It combines features of pyroptosis, apoptosis, and necroptosis.
• PANoptosis is regulated by PANoptosomes during infection and disease.

Purpose of the Study:

• To review the molecular mechanisms of PANoptosis in infection and disease.
• To highlight the role of PANoptosis in pathological processes.
• To discuss the therapeutic potential of targeting PANoptosis.

Main Methods:

• Literature review of studies on PANoptosis.
• Analysis of molecular mechanisms.
• Synthesis of findings on disease relevance and therapeutic strategies.

Main Results:

• PANoptosis is triggered by pathogen components sensed by PANoptosomes.
• It contributes to pathogen clearance and inflammation.
• PANoptosis is implicated in renal, myocardial, nervous system diseases, and cancer.

Conclusions:

• PANoptosis is a crucial pathway in host defense and disease pathogenesis.
• Targeting PANoptosis may offer novel therapeutic strategies for systemic disorders.
• Further research is needed to fully elucidate PANoptosis mechanisms and therapeutic applications.