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Updated: Jun 28, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
[Plasticization strengthening of the structure of porous biocompatible biodegradable matrices based on
A V Mironov1,2, A V Vasilyev1, I A Nedorubova1,3
1Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective:
Study of changes in the physico-mechanical and structural characteristics of highly porous matrices based on biocompatible biodegradable polyester - polylactoglycolide.
Materials And Methods:
Samples in the form of a porous polymer fiber were obtained by extrusion of a 10% solution of PLG/TG. The physical and mechanical properties of the material were investigated using a tensile test, the tensile rate was 1 mm/min, the measurement limit was 100% strain or a load of 500 N. The features of the macro- and microstructure of the samples were studied using a stereoscopic optical microscope Bresser Advance (Bresser, Germany) with a digital camera. The hardness measurements of the samples were carried out on a nanohardness meter by instrumental indentation. When studying the adhesion of MMSCs to the surface of matrices, a quantitative assessment of cellular adhesion was performed by calculating at least 15 fields of view in the ImageJ program (NIH, USA).
Results:
It has been found that as the plasticizer treatment time increases, the strength and modulus of elasticity of the samples increase, but this dependence is not linear. However, along with a significant improvement in physical and mechanical properties, plasticization changes the surface structure of the material, which, in turn, affects cellular adhesion. A decrease in the surface roughness of the samples from 1 micron to 200 nm leads to a decrease in the adhesion of MMSCs on the matrices, compared with untreated samples.
Conclusion:
Plasticization treatment of polylactoglycolide not only improves the physico-mechanical properties of PLG matrices, but also optimizes their surface for a specific type of cells.
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