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Updated: Jan 7, 2026

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
[The night has many faces: When schistocytes step out of line]
Sharon Appert1,2, Cyrill Rütsche3, Ilias Stagakis4
1Klinik für Allgemeine Innere Medizin / Hausarztmedizin und Notfallmedizin, HOCH Health Ostschweiz, Kantonsspital St. Gallen, St. Gallen.
Introduction:
We present a case study of a patient with paroxysmal nocturnal haemoglobinuria (PNH) which first presented clinically as a haemolytic crisis, potentially triggered by a SARS-CoV-2 infection. This case highlights the diagnostic challenges involved in distinguishing between PNH and thrombotic microangiopathy (TMA), particularly in emergency situations. Administering eculizumab early on, as it is effective in treating both diseases, was crucial in stabilising the patient before a definitive diagnosis could be confirmed.
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