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Asymmetric Partial Reductions of Pyridines
Ashlyn Bohn1, Benjamin M Cipriano1, Peter Wipf1
1Department of Chemistry, University of Pittsburgh, Pittsburgh PA 15260, USA.
Abstract:
The asymmetric partial reduction of substituted pyridines represents a direct and versatile strategy to access chiral di- and tetrahydropyridines, which are present in many natural products and active pharmaceutical ingredients (APIs). However, this methodology remains significantly underdeveloped when compared to the numerous exhaustive asymmetric reductions of pyridines to fully saturated piperidines, and is currently still limited to the synthesis of tetrahydropyridines. In this Opinion, we highlight the benefits, challenges, and current scope of asymmetric partial pyridine reductions, emphasizing prospective future directions to address significant gaps in the current literature.
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