Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

7.8K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
7.8K
General Transcription Factors01:30

General Transcription Factors

6.6K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.6K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.3K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.3K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.4K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.4K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

9.7K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mesenchymal stem cells-derived extracellular vesicles as a novel drug delivery carrier: engineering strategies and clinical safety estimation.

Frontiers in molecular biosciences·2026
Same author

Interpretable machine learning for optimization of ultrasound-assisted polysaccharide extraction using natural deep eutectic solvents: From yield enhancement to structural and antioxidant activity validation.

Bioresource technology·2026
Same author

Iridoids in medicinal herbs for the treatment of cardiovascular diseases: Ethnopharmacology, phytochemistry, and pharmacology.

Journal of ethnopharmacology·2026
Same author

Persistent Near-Linear Relationship Between Global Stress and Mean Atomic Bond Strain in Metallic Glasses Despite Significant Local Nonaffine Displacements.

Materials (Basel, Switzerland)·2026
Same author

Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.

Frontiers in microbiology·2026
Same author

Plasma exosomal fibroblast activation protein: a novel biomarker links fatty acid metabolic dysregulation to systemic lupus erythematosus.

Arthritis research & therapy·2026
Same journal

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

Frontiers in immunology·2026
Same journal

Circadian control of immune homeostasis in cardiovascular health and disease.

Frontiers in immunology·2026
Same journal

An IHC-derived TLS-CD8-macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC.

Frontiers in immunology·2026
Same journal

AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.

Frontiers in immunology·2026
Same journal

Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.

Frontiers in immunology·2026
Same journal

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K

Transcription factor c-Maf: a checkpoint that programs autoimmunity.

Na Liu1, Jin Zhang2, Pingping Wang3

  • 1Center of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in Immunology
|December 12, 2025
PubMed
Summary
This summary is machine-generated.

The transcription factor c-Maf regulates immune cell development and function. It suppresses harmful inflammation while promoting protective immunity, showing therapeutic promise for autoimmune diseases.

Keywords:
autoimmune diseasesautoimmunityc-Mafimmune checkpointinflammation

More Related Videos

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.1K
A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.9K

Related Experiment Videos

Last Updated: Jan 8, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.9K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.1K
A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.9K

Area of Science:

  • Immunology
  • Molecular Biology
  • Transcription Factors

Background:

  • c-Maf is a key regulator in immune cell development and function.
  • It controls immune cell growth, differentiation, and responses.
  • Dysregulation of c-Maf is implicated in immune-related disorders.

Purpose of the Study:

  • To review the mechanistic role of c-Maf in autoimmunity and inflammation.
  • To explore c-Maf's associated signaling networks.
  • To highlight c-Maf's therapeutic potential in autoimmune diseases.

Main Methods:

  • Literature review of studies on c-Maf in immunity.
  • Analysis of c-Maf's role in immune cell signaling pathways.
  • Examination of c-Maf's function in models of inflammation and autoimmunity.

Main Results:

  • c-Maf acts as a critical regulator of immune cell homeostasis.
  • It exhibits dual functions: suppressing pathological inflammation and promoting protective immunity.
  • Associated signaling networks modulate autoimmune responses.

Conclusions:

  • c-Maf is a crucial immune checkpoint with significant therapeutic potential.
  • Targeting c-Maf may offer novel strategies for treating autoimmune diseases.
  • Further research into c-Maf signaling is warranted for clinical applications.