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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
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Mineralizing Elastin-Like Protein Microgels.

Ieva Sapjanskaite1,2, Abshar Hasan1,2,3, José Carlos Rodríguez-Cabello4

  • 1School of Pharmacy, University of Nottingham, Nottingham, UK.

Journal of Biomedical Materials Research. Part A
|December 12, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed injectable elastin-like recombinamer (ELR) microgels for bone regeneration. These microgels facilitate organized apatite mineralization and show promise for hard tissue repair applications.

Keywords:
elastin‐like recombinamershydroxyapatitemicrogelsorganized mineralizationprotein‐based biomineralization

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Mineralization

Background:

  • Mineralized tissues like bone and enamel rely on organic-inorganic interactions.
  • Elastin-like recombinamers (ELRs) are used in tissue engineering but not yet as microgels.
  • Organized mineralization is key for biological tissues and engineered materials.

Purpose of the Study:

  • To develop injectable ELR microgels for organized apatite mineralization.
  • To explore ELR microgels as scaffolds for hard tissue repair.
  • To assess the mineralization capacity and biocompatibility of ELR microgels.

Main Methods:

  • Fabrication of injectable ELR microgels via water-in-oil emulsification.
  • Mineralization of ELR microgels to form apatite-like crystals.
  • Characterization using SEM, TEM, FTIR, XRD, and cell viability assays.

Main Results:

  • Successfully fabricated injectable ELR microgels capable of organized mineralization.
  • Achieved approximately 20 wt% mineral content with hydroxyapatite structure.
  • Demonstrated low cytotoxicity (>90% hMSC viability) and enhanced osteogenic potential (40% ALP increase).

Conclusions:

  • ELR microgels offer a versatile platform for mineralized tissue engineering.
  • The microgel format enhances surface area and handling for applications like injectable scaffolds and 3D bioprinting.
  • ELR microgels show significant potential for advancing hard tissue repair strategies.