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Published on: October 4, 2019
Benzopyran derivatives from Melicope pteleifolia
Pham Thi Cham1, Le Thi Vien1, Ninh Thi Ngoc1
1Department of Marine Medicinal Materials, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Vietnam.
None:
Phytochemical investigation of M. pteleifolia branches and leaves led to the isolation of seven benzopyran derivatives, including five new ones named melicopols A - E (2 - 6). The chemical structures were confirmed by extensive analysis of the 1D, 2D NMR, CD, and HR-QTOF mass spectra. The absolute configuration 1'S of leptol A (1) was firstly confirmed by experimental and calculated ECD data. Their cytotoxic activity on three human cancer cell lines HepG2 (hepatoma), SK-LU-1 (lung), and MCF7 (breast) was also evaluated using SRB assay.
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