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Divergent Synthesis of Highly Functional 3-Trifluoromethylated Dihydropyrroles and Pyrroles via 6π-Photocyclization
Meiqiong Li1, Yuping Zhu1, Daohong Yu1
1Jiangxi Province Key Laboratory of Synthetic Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, PR China.
Abstract:
Presented herein is a solvent-directed selective synthesis of 3-trifluoromethylated dihydropyrroles and pyrroles based on the anaerobic or aerobic reaction of trifluoromethyl-substituted dienamines via 6π-photocyclization. The work provides a robust protocol for the effective functionalization of dienamine derivatives, leading to the concise and selective assembly of pyrrole-related scaffolds bearing a pharmaceutically privileged CF3 unit. This novel strategy features a photocatalyst-free process, divergent synthesis, formal hydroalkenylation, excellent regioselectivity, wide functional group tolerance, and operational convenience.
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