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Related Concept Videos

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.6K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.6K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

1.2K
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
1.2K

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Related Experiment Video

Updated: Jan 8, 2026

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
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In-Line NMR Diagnostics of Hydroformylation Provided by the Segmented-Flow Microfluidic Regime.

Mahmoud E A Eid1,2, Maria V Nenasheva3, Aleksei N Bulgakov1

  • 1The Smart Materials Research Institute, Sladkova 178/24, 344090 Rostov-on-Don, Russia.

Analytical Chemistry
|December 14, 2025
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Summary

This study introduces fast in-line monitoring of hydroformylation using 1H NMR spectroscopy in microfluidics. This method enhances reaction screening and optimization without costly deuterated solvents.

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Area of Science:

  • Chemical Engineering
  • Organic Chemistry
  • Spectroscopy

Background:

  • Hydroformylation converts olefins to aldehydes and alcohols, crucial industrial processes.
  • Current methods use homogeneous Rh/Co catalysts in batch mode, facing challenges in monitoring.
  • Microfluidic systems offer enhanced mass/heat transfer but require sensitive in situ characterization.

Purpose of the Study:

  • To develop a fast, in-line spectroscopic method for monitoring hydroformylation in microfluidic reactors.
  • To overcome limitations of existing in situ techniques regarding sensitivity and sample preparation.
  • To enable efficient screening and optimization of hydroformylation under microfluidic conditions.

Main Methods:

  • Utilized 1H NMR spectroscopy for real-time monitoring within a microfluidic segmented flow.
  • Implemented an in-line approach to avoid sample extraction and preparation.
  • Avoided the need for expensive deuterated solvents.

Main Results:

  • Achieved fast in-line monitoring of hydroformylation products directly in the segmented flow.
  • Demonstrated a method that bypasses complex sample preparation and solvent replacement.
  • Showcased the potential for improved reaction monitoring and control in microfluidic systems.

Conclusions:

  • 1H NMR spectroscopy in microfluidic segmented flow provides a sensitive and efficient method for hydroformylation monitoring.
  • This approach simplifies process analysis, reducing costs and complexity.
  • Opens new avenues for rapid screening and optimization of catalytic reactions in microreactors.