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Updated: Jan 8, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Signaling of Mitogenic and Metabolic Activities by Fibroblast Growth Factors

Patience Salvalina Okoto1, Zeina Alraawi1, Thallapuranam Krishnaswamy Suresh Kumar1

  • 1Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA.

Journal of Cellular Signaling
|December 15, 2025
PubMed

Insights

Fibroblast growth factors (FGFs) are key signaling molecules. This review explores how FGFs and their receptors interact to regulate cell functions, focusing on mitogenic and metabolic roles.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Fibroblast growth factors (FGFs) are crucial signaling molecules involved in fundamental biological processes.
  • FGFs exert their functions by forming complexes with tyrosine kinase FGF receptors and cofactors.
  • The diverse roles of FGFs are influenced by tissue type, developmental stage, receptor availability, and environmental factors like temperature and pH.

Purpose of the Study:

  • To review the actions of mitogenic and metabolic FGFs.
  • To elucidate the interactions between FGFs and their receptors.
  • To understand how these interactions trigger specific cellular functions.

Main Methods:

  • Literature review of scientific publications on FGFs and their receptors.
  • Analysis of studies focusing on mitogenic and metabolic FGF functions.
  • Synthesis of information regarding FGF-receptor complex formation and signaling pathways.

Main Results:

  • FGFs regulate critical cellular processes including migration, proliferation, differentiation, angiogenesis, and survival.
  • Specific FGFs, their receptors, and environmental conditions dictate FGF activity in different contexts.
  • The interaction between FGFs and receptors is central to initiating downstream signaling cascades.

Conclusions:

  • FGFs are versatile signaling proteins with context-dependent functions.
  • Understanding FGF-receptor dynamics is essential for comprehending cell regulation.
  • This review highlights the importance of mitogenic and metabolic FGFs in cellular processes.
Keywords:
Cell signalingFibroblast growth factorsMetabolic FGFsMitogenic FGFs

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