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Updated: Feb 28, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Pathology and Therapeutic Significance of Fibroblast Growth Factors
Oshadi Edirisinghe1, Gaëtane Ternier2, Thallapuranam Krishnaswamy Suresh Kumar1,2
1Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
Abstract:
The fibroblast growth factor (FGF) family includes 22 proteins in humans. Based on their mode of action, there are three families of FGFs: paracrine FGFs (FGF 1-10, 16, 17, 18, 20, and 22), intracrine FGFs (FGF 11-14), and endocrine FGFs (FGF 19, 21, and 23). FGF signaling plays critical roles in embryonic development, tissue repair, regeneration, angiogenesis, and metabolic regulation. They exert their cellular functions by binding, dimerization, and activation of transmembrane FGF receptors (FGFRs). Aberrant FGF signaling is associated with various human diseases. Thus, understanding the unique properties of FGF signaling will help to explore new therapeutic interventions against FGF-mediated pathological conditions. This review will discuss the differential expression and regulation of each FGF under normal human physiological and pathological conditions. Moreover, we will outline current therapeutics and treatment strategies that have been developed against FGF-related pathology.
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