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Assessing liquid light guides in diffuse correlation spectroscopy systems.

Yuanzhe Zhang1, Mingliang Pan1, Chenxu Li1

  • 1University of Strathclyde, Department of Biomedical Engineering, Glasgow, UK.

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|December 15, 2025
PubMed
Summary
This summary is machine-generated.

Replacing conventional fibers with liquid light guides in diffuse correlation spectroscopy (DCS) significantly boosts signal quality. This advancement enhances blood flow monitoring accuracy without compromising safety limits.

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Area of Science:

  • Biomedical Optics
  • Physiological Measurement

Background:

  • Diffuse correlation spectroscopy (DCS) is a key noninvasive optical method for assessing tissue blood flow.
  • Accurate DCS requires high signal-to-noise ratio (SNR), often limited by tissue safety constraints on optical irradiance.

Purpose of the Study:

  • To investigate the use of liquid light guides (LLGs) as an alternative to multi-mode fibers (MMFs) for DCS illumination.
  • To enhance DCS SNR and blood flow estimation sensitivity within safety limits.

Main Methods:

  • Experimental comparison of LLG and MMF illumination systems in DCS.
  • Evaluation of photon throughput, illumination uniformity, and SNR under identical irradiance constraints.

Main Results:

  • LLG illumination provided a more uniform profile and higher photon throughput than MMF.
  • The LLG-based DCS system achieved approximately a three-fold increase in SNR compared to the MMF system.
  • Enhanced SNR was achieved without exceeding maximum permissible exposure limits.

Conclusions:

  • Liquid light guides effectively enhance DCS sensitivity and SNR by improving light delivery efficiency and uniformity.
  • LLG illumination offers a viable strategy for improving noninvasive blood flow monitoring in biomedical applications.
  • This technique enables more accurate and sensitive blood flow measurements within established safety guidelines.