Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparative evaluation of proximal caries detection methods using human, artificial intelligence, and micro-CT assessments.

Journal of dentistry·2026

Same author

Immune (dys)function in obsessive-compulsive disorder.

Brain, behavior, and immunity·2026

Same author

Influence of Surface Conditioning Protocols and Lining Materials on the Fracture Resistance of Aged 3D-Printed Onlay Restorations.

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]·2026

Same author

Response to: Commentary on "Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study".

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026

Same author

Mental Health, Coping Strategies and Self-Care Practices Among Professionals Who Work With People Who Experience or Have Experienced Domestic Violence: A Quantitative Study.

Scandinavian journal of caring sciences·2026

Same author

Dysfunctional Brain Circuits Overlap in Lesional and Idiopathic Obsessive-Compulsive Disorder.

Biological psychiatry·2026

Search research articles

Related Experiment Video

Updated: May 2, 2026

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive

Nelson Descalco¹, Gonçalo Cotovio², Ana Maia³

¹Champalimaud Research and Clinical Centre, Champalimaud Foundation; NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa; Department of Psychiatry and Mental Health, Unidade Local de Saúde Almada-Seixal; nelson.descalco@research.fchampalimaud.org.

Journal of Visualized Experiments : Jove

|December 15, 2025

Summary

This study details a specific transcranial magnetic stimulation (TMS) protocol for treating obsessive-compulsive disorder (OCD). The protocol involves targeted brain stimulation and symptom provocation, offering a framework for clinicians and researchers.

More Related Videos

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Related Experiment Videos

Last Updated: May 2, 2026

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Area of Science:

Neuroscience
Psychiatry

Background:

Obsessive-compulsive disorder (OCD) is a chronic condition with limited treatment efficacy.
Transcranial magnetic stimulation (TMS) is an emerging neuromodulation technique for OCD.

Purpose of the Study:

To provide a detailed, step-by-step TMS protocol for OCD aligned with FDA clearance.
To guide clinicians and researchers in implementing TMS for OCD treatment.

Main Methods:

High-frequency (20 Hz) TMS applied to the anterior cingulate cortex/dorsomedial prefrontal cortex (ACC/dmPFC).
Protocol includes 30 sessions over 6 weeks, 2000 pulses per session, with individualized symptom provocation.
Coil targeting, stimulation parameters, and patient preparation are outlined.

Main Results:

The article presents a structured framework for TMS application in OCD.
Guidance on patient preparation, coil targeting, stimulation settings, and symptom provocation is provided.

Conclusions:

This detailed protocol facilitates the clinical implementation of TMS for OCD.
It offers a standardized approach to neuromodulation for treatment-resistant OCD.