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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Related Experiment Video

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Inducing Apical Periodontitis in Mice
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FOXP3+ T Cells-An Emerging Evidence in Periodontitis Therapeutics.

Revan Birke Koca Ünsal1, Akira Hasuike2, Tamer Badawy3,4

  • 1Schulich School of Medicine & Dentistry Western University, London, Canada.

Clinical and Experimental Dental Research
|December 16, 2025
PubMed
Summary

The balance between regulatory T cells (Tregs) and Th17 cells is key in periodontitis progression. Enhancing Treg function may offer new therapies for this inflammatory gum disease.

Keywords:
FOXP3+ regulatory T cellsTregsimmunomodulationperiodontal diseasesperiodontitis

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Area of Science:

  • Immunology
  • Periodontology

Background:

  • FOXP3+ regulatory T cells (Tregs) are crucial for immune homeostasis and controlling inflammation.
  • Periodontitis is a chronic inflammatory disease where the immune system attacks gum tissues.

Purpose of the Study:

  • To review the interaction between FOXP3+ regulatory T cells and Th17 cells in periodontitis progression.
  • To explore potential immunomodulatory therapeutic strategies.

Main Methods:

  • Literature review of studies on FOXP3+ Tregs, Th17 cells, and periodontitis.
  • Descriptive summary of findings.

Main Results:

  • An imbalance favoring pro-inflammatory Th17 cells over Tregs exacerbates periodontitis, leading to bone loss via IL-17 and RANKL.
  • Periodontitis's inflammatory environment impairs Treg stability and function.
  • Systemic conditions like diabetes and obesity worsen Treg dysfunction, accelerating periodontal damage.

Conclusions:

  • Understanding Treg-Th17 interactions is vital for developing targeted therapies for periodontitis.
  • Future research should explore Treg expansion, adoptive transfer, and IL-17 inhibition, balancing efficacy with immunosuppression risks.