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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
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Mapping human neurodevelopment-Brain organoids meet lineage tracing
Carla Liaci1,2, Giorgia Quadrato1,2
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
FEBS Letters
|December 16, 2025
Summary
Brain organoids enable longitudinal studies of human development, offering a dynamic
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- Traditional in vitro models lack the temporal dimension crucial for studying human development and disease.
- Brain organoids offer a self-organizing 3D system for longitudinal analysis of developing human tissues.
- Genetic amenability of organoids allows integration with advanced synthetic biology tools.
Purpose of the Study:
- To review the application of brain organoids in understanding human developmental processes.
- To highlight novel lineage tracing tools for studying cell lineage and temporal progression.
- To discuss limitations and future directions for brain organoid technology.
Main Methods:
- Review of current literature on brain organoids and lineage tracing technologies.
- Integration of omics technologies with lineage tracing for high-resolution analysis.
- Focus on studies developing dedicated lineage tracing tools for brain organoids.
Main Results:
- Brain organoids provide unprecedented resolution for dissecting complex human biological processes.
- Novel lineage tracing systems integrated with omics technologies reveal temporal progression.
- Studies highlight the potential of brain organoids to model human brain development.
Conclusions:
- Brain organoids are powerful tools for studying human developmental processes, including cell lineage and temporal progression.
- Advanced lineage tracing tools are crucial for enhancing the fidelity and translational relevance of organoid models.
- Further improvements in technology are needed to fully realize the potential of brain organoids in modeling brain development and disease.
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