Related Experiment Video
Updated: Jan 8, 2026

14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
17.0K
Total synthesis of maltepolide F
Bashweshawar S Dhulshette1,2, Subhash Ghosh1,2
1Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India. subhash@iict.res.in.
Organic & Biomolecular Chemistry
|December 16, 2025
Abstract
None:
Herein, we present the total synthesis of the polyketide macrolide maltepolide F. D-Mannitol serves as the chiral pool material for constructing the tetrahydrofuran unit. Key steps in the synthesis include cyclo-etherification, Brown asymmetric allylation, the Evans aldol reaction, Yamaguchi esterification, and intramolecular Heck cyclization.

