Comparative Study of Monopolar Radiofrequency and High-Intensity Focused Ultrasound for Facial Rejuvenation: A
Woo Jin Choi1, Ye Ji Jang2, Da Yeon Jung2
1Bundang Renewme Skin Clinic, Gyeonggi, Korea.
Summary
For facial rejuvenation, combining monopolar radiofrequency (RF) and high-intensity focused ultrasound (HIFU) is effective. Applying RF before HIFU showed superior wrinkle reduction compared to the reverse sequence.
Area of Science:
- Aesthetic medicine and dermatology
- Non-invasive cosmetic procedures
- Skin rejuvenation technologies
Background:
- Growing demand for non-surgical anti-aging solutions.
- Popularity of monopolar radiofrequency (RF) and high-intensity focused ultrasound (HIFU) for skin laxity and wrinkles.
- Uncertainty regarding the optimal sequence for combined RF and HIFU treatments.
Purpose of the Study:
- To assess the efficacy and safety of sequential RF and HIFU for facial rejuvenation.
- To determine the impact of treatment sequence on clinical outcomes.
- To compare RF followed by HIFU versus HIFU followed by RF.
Main Methods:
- Split-face study design involving 24 Korean adults.
- Comparison of two sequences: RF then HIFU, and HIFU then RF.
- Clinical assessments at 30 and 90 days, with 3D camera analysis for wrinkles and pores.
Main Results:
- Both sequences yielded clinical improvements with minimal adverse effects.
- Monopolar RF followed by HIFU demonstrated slightly superior wrinkle reduction based on 3D camera analysis.
- Histological analysis showed increased collagen (types I, III, IV) and laminin, with no significant sequence-dependent differences.
Conclusions:
- Monopolar RF and HIFU are safe and effective for facial rejuvenation.
- The sequence of RF followed by HIFU offers enhanced wrinkle reduction compared to the reverse order.
- Further research may refine optimal treatment protocols for combined modalities.


