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Updated: Jan 8, 2026
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Chromatin Isolation by RNA Purification ChIRP
Published on: March 25, 2012
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Multi-layered gene regulation by long non-coding RNAs: from chromatin to genome architecture
Jaeryoung Kyung1, Minjae Kim1, Hye-Rim Shin1
1Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
BMB Reports
|December 17, 2025
Summary
Long non-coding RNAs (lncRNAs) fine-tune gene expression by coordinating epigenomic control and genome architecture. Their dysregulation contributes to human diseases, linking epigenetic programs with genome topology.
Area of Science:
- Molecular Biology
- Genetics
- Epigenetics
Background:
- Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
- Their diverse functions involve epigenomic control, from local chromatin to nuclear organization.
Conclusions:
- lncRNAs integrate epigenetic programs with genome topology for spatiotemporal gene expression.
- Dysfunctional lncRNAs link aberrant epigenetic and architectural regulation to pathogenesis.
- Understanding lncRNA mechanisms offers insights into normal physiology and disease.
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