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Related Concept Videos

NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

2.1K
NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
2.1K
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

1.0K
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
1.0K
¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

1.4K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.4K
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

592
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
592
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)01:19

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

1.4K
Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
1.4K

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Updated: Jan 8, 2026

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the &#181;s-ms Timescale
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Scalable cyberinfrastructure for experimental NMR data.

Jeffrey C Hoch1,2, Katherine Henzler-Wildman3,4, Arthur S Edison5,6,7

  • 1Department of Molecular Biology & Biophysics, UConn Health, Farmington, CT, 06030, USA.

Scientific Data
|December 17, 2025
PubMed
Summary
This summary is machine-generated.

The Network for Advanced NMR (NAN) provides a unified cyberinfrastructure for Nuclear Magnetic Resonance (NMR) facilities. This resource democratizes access to advanced NMR instruments and data, fostering open and reproducible scientific research.

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Area of Science:

  • Biomedicine
  • Chemistry
  • Material Science

Background:

  • Nuclear Magnetic Resonance (NMR) facilities are often fragmented, limiting access to advanced instrumentation and data.
  • Emerging data standards in biomedicine, chemistry, and material science require robust infrastructure for data management and sharing.

Purpose of the Study:

  • To establish a novel distributed resource, the Network for Advanced NMR (NAN), connecting NMR facilities.
  • To create a scalable cyberinfrastructure supporting NMR data harvesting, management, and discovery.
  • To enable emerging data standards and democratize access to NMR resources.

Main Methods:

  • Integration of NMR facilities around a centralized hub for identity management, resource discovery, and access control.
  • Automated data harvesting via the NAN data transport system (NDTS).
  • Metadata-rich data archiving with interactive web-based tools for data browsing, editing, and publishing.

Main Results:

  • NAN provides access to the first open-access 1.1 GHz NMR instruments in the USA.
  • Implementation of tools for facility and laboratory data management.
  • Development of NAN knowledgebases with standardized protocols, parameters, and datasets.

Conclusions:

  • NAN successfully democratizes access to advanced NMR resources.
  • The platform fosters open, reproducible science through enhanced data sharing and management.
  • NAN supports the development and adoption of emerging data standards in scientific research.