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Effectiveness of an Individualized Comprehensive Weight Management Program in Perimenopausal Women: An Open-label

Aditi Verma1, Piyush Ranjan2, Archana Kumari3

  • 1Department of Home Science, University of Delhi, New Delhi, India.

Journal of Mid-Life Health
|December 19, 2025
PubMed
Summary
This summary is machine-generated.

Intensive lifestyle interventions significantly reduced weight, improved metabolic health, and enhanced psychological well-being in perimenopausal women. This approach is crucial for managing menopausal transition symptoms and preventing disease.

Keywords:
Clinical triallifestyle interventionmenopauseperimenopauserandomized control trialweight loss

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Area of Science:

  • Reproductive Medicine
  • Metabolic Health
  • Behavioral Science

Background:

  • Weight management is critical during menopause for symptom control and disease prevention.
  • Intensive lifestyle interventions show promise for significant weight loss in this demographic.
  • This study evaluated such an intervention during the menopausal transition.

Purpose of the Study:

  • To assess the efficacy of an intensive lifestyle intervention for weight management in perimenopausal women.
  • To evaluate the intervention's impact on metabolic markers and psychological well-being.
  • To compare outcomes between an intervention group and a standard care control group.

Main Methods:

  • 160 perimenopausal women were randomized into intervention (n=80) and control (n=80) groups.
  • The intervention included diet, physical activity, psychological support, and behavioral modification.
  • The control group received standard care, with analysis after 6 months on 134 participants.

Main Results:

  • The intervention group showed significant reductions in weight, BMI, waist circumference, waist-to-hip ratio, and fat percentage (P < 0.01).
  • Improvements were observed in blood pressure, glycated hemoglobin, cholesterol, triglycerides, and VLDL (P < 0.05).
  • 42.5% in the intervention group achieved >5% weight loss versus 2.5% in the control group, with improved mood and activity levels.

Conclusions:

  • Intensive lifestyle interventions are effective for improving weight, metabolic health, and psychological well-being in perimenopausal women.
  • This comprehensive approach significantly aids health management during menopausal transition.
  • The findings highlight the intervention's importance for this specific demographic.