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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Dentin Remineralization Associating Peptide- and Particle-Assisted Strategies.

A L Campos1, H S Vilela1, R B Trinca1

  • 1School of Dentistry, Department of Biomaterials and Oral Biology, University of São Paulo, São Paulo, SP, Brazil.

Journal of Dental Research
|December 20, 2025
PubMed
Summary
This summary is machine-generated.

Combining polymer-induced liquid precursor (PILP) and dicalcium phosphate dihydrate (DCPD) composite significantly enhances dentin remineralization. This dual approach restores mineral content and mechanical properties more effectively than individual treatments alone.

Keywords:
calcium phosphatesdental pulp cavityelastic modulusnanohardnesspoly(aspartic acid)resin composites

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Area of Science:

  • Biomaterials Science
  • Dental Research
  • Mineralization Studies

Background:

  • Dentin demineralization poses a significant challenge in restorative dentistry.
  • Current remineralization strategies often have limitations in efficacy and speed.
  • Investigating novel combinations of biomaterials can lead to improved treatment outcomes.

Purpose of the Study:

  • To evaluate the efficacy of the polymer-induced liquid precursor (PILP) process for dentin remineralization.
  • To assess an experimental composite containing dicalcium phosphate dihydrate (DCPD) particles for dentin remineralization.
  • To determine if combining PILP pretreatment with DCPD composite enhances dentin remineralization compared to individual methods.

Main Methods:

  • Artificial dentin lesions were created and divided into four groups: control, PILP, DCPD, and PILP + DCPD.
  • Remineralization was assessed over 28 days using mineral-to-matrix ratio (MMR) via FTIR and nanoindentation for elastic modulus (EM).
  • Microscopy techniques (SEM, EDS, TEM, SAED) were used for morphological and compositional analysis.

Main Results:

  • All groups showed MMR recovery, but only the PILP + DCPD group reached sound dentin levels by 14 days.
  • The PILP + DCPD group exhibited significantly higher elastic modulus (EM) in both external and internal lesion areas compared to control.
  • EM recovery in the PILP + DCPD group reached 57% of sound dentin, significantly higher than PILP (18%) or DCPD (31%) alone.

Conclusions:

  • The combination of PILP pretreatment and DCPD composite significantly enhances dentin remineralization.
  • This synergistic approach restores both mineral content and mechanical properties of demineralized dentin more effectively.
  • The PILP + DCPD strategy represents a promising advancement for treating artificial dentin lesions.