Related Experiment Video
Updated: Jan 8, 2026
08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
3.4K
BX3-Mediated Arene Borylation: Concepts, Scope, and Mechanistic Insight
Rahul Bangari1, Rudraa Singh Rajpoot1, Naoto Chatani2,3
1Department of Chemistry, IIT Dharwad, Chikka Malligwad, Karnataka, India.
Chemistry, an Asian Journal
|December 21, 2025
Summary
Transition metal-free arene C‒H borylation offers a sustainable route to arylborane synthesis using boron trihalides. This review analyzes the mechanisms of these metal-free reactions for future methodology development.
Area of Science:
- Organic Chemistry
- Catalysis
- Sustainable Chemistry
Background:
- Precious metal-catalyzed borylation reactions present limitations.
- Transition metal-free arene C‒H borylation offers a sustainable alternative.
- Electrophilic boron trihalides are key reagents in metal-free borylation.
Purpose of the Study:
- To critically analyze the mechanistic pathways of transition metal-free arene C‒H borylation.
- To emphasize the elementary steps in BX3-mediated C-H bond functionalization.
- To provide a framework for interpreting existing studies and designing future methods.
Main Methods:
- Review of existing literature on metal-free borylation.
- Mechanistic analysis of BX3-mediated C-H functionalization.
- Focus on electrophilic activation of arene π-electron systems.
Main Results:
- Detailed examination of mechanistic pathways in metal-free borylation.
- Identification of key elementary steps in BX3-mediated reactions.
- Conceptual framework for understanding and designing borylation methodologies.
Conclusions:
- Transition metal-free borylation is a viable and sustainable synthetic strategy.
- Understanding mechanistic pathways is crucial for optimizing these reactions.
- This review provides insights for advancing metal-free borylation chemistry.
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