Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosurgery01:30

Psychosurgery

1.3K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
1.3K
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visual environment shapes the social dynamics of coloration and competition in an African Cichlid Fish.

The Journal of experimental biology·2026
Same author

The extracellular matrix as a dynamic regulator of brain function and plasticity.

Neurobiology of disease·2026
Same author

DNA methylation of the endothelin receptor B makes blue fish yellow.

Nature communications·2025
Same author

Convergent Evolution and the Epigenome.

Epigenomes·2025
Same author

Peripheral inflammation is accompanied by cerebral hypoperfusion in mice.

Frontiers in pain research (Lausanne, Switzerland)·2025
Same author

Background color matching influences sexual behavior, growth, and mortality rate in an African cichlid fish.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K

Pain Research and Treatment: Policy Implications.

Maral Tajerian1,2, Sebastian Alvarado1,2

  • 1Department of Biology, Queens College, City University of New York, Flushing, NY, USA.

Policy Insights From the Behavioral and Brain Sciences
|December 22, 2025
PubMed
Summary

Chronic pain is now recognized as a disease, not just a symptom. Recent advances in preclinical research and novel therapeutic approaches offer new hope for effective pain management, moving beyond traditional opioid reliance.

Keywords:
animal modelsartificial intelligencechronic painclinician educationopiatesopioidspainpreclinical models

More Related Videos

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.8K
Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

9.9K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.8K
Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

9.9K

Area of Science:

  • Neuroscience
  • Pain Medicine
  • Pharmacology

Background:

  • Chronic pain is increasingly understood as a distinct disease, necessitating new research directions.
  • Traditional pain management often relies on opioids, leading to significant side effects and limited efficacy.
  • Preclinical studies and clinical trials for novel analgesics have yielded underwhelming results.

Purpose of the Study:

  • To provide an overview of recent advancements in pain research.
  • To explore novel diagnostic and treatment strategies for pain.
  • To discuss considerations for animal care in pain research.

Main Methods:

  • Review of preclinical research findings.
  • Analysis of emerging diagnostic techniques.
  • Evaluation of novel therapeutic interventions.
  • Examination of ethical considerations in animal research.

Main Results:

  • Significant shifts in pain research paradigms over the past two decades.
  • Development of non-opioid-based pain management strategies.
  • Improved understanding of pain mechanisms through preclinical models.
  • Emerging novel approaches to pain diagnosis and treatment.

Conclusions:

  • Pain research, diagnosis, and treatment have evolved significantly.
  • A paradigm shift away from opioid-centric pain management is underway.
  • This report offers a guide for policy changes informed by scientific evidence and societal needs.