Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Olfactory Impairment and Depression: A Systematic Review and Meta-Analysis.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Cognitive impairment, no dementia and hospitalizations - the role of formal and informal care: A population-based cohort study.

International journal of nursing studies·2026
Same author

Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal population-based Swedish cohorts.

Neurobiology of aging·2026
Same author

Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.

Alzheimer's research & therapy·2026
Same author

Neuropsychiatric symptoms and dementia development: a 15-year population-based study.

The journal of prevention of Alzheimer's disease·2026
Same author

Blood biomarkers of Alzheimer's disease and 15-year decline in cognitive and motor functions in older adults.

Journal of internal medicine·2026

Related Experiment Video

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

Alzheimer's Imaging Consortium.

Javier Oltra1, Zuzana Wallin Ištvánfyová2,3, Grégoria Kalpouzos1

  • 1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Stockholm, Sweden.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Olfactory deficits in subjective cognitive impairment (SCI) are linked to amyloid levels and frontal lobe structure. These findings suggest early Alzheimer's disease (AD) mechanisms involve olfactory dysfunction.

More Related Videos

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Related Experiment Videos

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

Area of Science:

  • Neuroscience
  • Neurology
  • Gerontology

Background:

  • Olfactory deficits are early indicators of dementia, including Alzheimer's Disease (AD).
  • Understanding olfactory dysfunction in pre-dementia stages is crucial for early detection.
  • This study investigates olfactory identification (OID) in relation to AD biomarkers and brain volumes.

Purpose of the Study:

  • To examine associations between cerebrospinal fluid (CSF) biomarkers and central olfactory system volumes with OID.
  • To analyze these associations in individuals with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and AD.
  • To identify potential early markers for dementia within the olfactory system.

Main Methods:

  • Recruited 154 SCI, 51 MCI, and 31 AD participants.
  • Assessed OID using the Sniffin' Sticks test.
  • Measured CSF biomarkers (Aβ42, p-tau181, NfL) and central olfactory system volumes (hippocampus, amygdala, entorhinal cortex, orbitofrontal cortex, insula, caudate).
  • Analyzed data using partial correlations and multiple linear regressions.

Main Results:

  • SCI participants (M=14.1) had better OID than MCI (M=12.7) and AD (M=12.8) groups.
  • In SCI, OID correlated with Aβ42 levels and orbitofrontal volume.
  • In MCI, OID correlated with hippocampal, parahippocampal, and caudate volumes.
  • In AD, OID correlated with hippocampal volume.
  • Linear regression showed Aβ42 and orbitofrontal volume predicted OID in SCI; NfL, entorhinal, and insula volumes predicted OID in MCI.

Conclusions:

  • Olfactory deficits in SCI are associated with amyloid levels and reduced orbitofrontal volume, indicating early roles for amyloid deposition and frontal lobe degeneration.
  • In MCI and AD, olfactory deficits may stem from degeneration in the medial temporal lobe and subcortical structures.
  • These findings highlight the potential of olfactory testing and associated neuroimaging/biomarkers for early dementia detection.