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Updated: Jan 8, 2026
05:17
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
751
Alzheimer's Imaging Consortium.
Sulakshna Aggarwal1, Priya Chatterjee2, Hitesh Pradhan2
1Centre for Brain Research, Bangalore, Karnataka, India.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
High homocysteine levels are linked to lower cognitive performance in rural Indians, regardless of vitamin B12 status. Early homocysteine screening may help identify individuals at risk for cognitive impairment.
Area of Science:
- Neurology
- Nutritional Neuroscience
- Aging Research
Background:
- Vitamin B12 impacts cognitive function, potentially via homocysteine levels.
- Limited data exists on Vitamin B12, homocysteine, and cognitive/brain changes in rural India.
Purpose of the Study:
- To investigate the association between Vitamin B12, homocysteine, and cognitive performance in a rural Indian aging population.
- To explore the relationship between these biomarkers and MRI-defined brain volumes.
Main Methods:
- Cross-sectional analysis of 2784 non-demented participants (aged 45+) from the CBR-SANSCOG cohort.
- Cognitive assessment using HMSE and COGNITO battery; MRI for brain volumes.
- Statistical analysis (General Linear Model) adjusted for multiple covariates.
Main Results:
- No association found between Vitamin B12 levels and cognitive performance or brain volumes.
- Increased homocysteine levels correlated with lower HMSE and visual attention scores.
- Higher homocysteine was associated with reduced hippocampal volume, independent of Vitamin B12.
Conclusions:
- Elevated homocysteine levels negatively impact cognitive performance in this population, irrespective of Vitamin B12.
- Serum homocysteine screening could identify individuals at risk for cognitive decline.
- Homocysteine may serve as a biomarker for early cognitive impairment detection.
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