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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

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Intensive blood pressure control reduced arterial stiffness, lowering dementia risk. Arterial stiffness is a key factor in cognitive decline and a potential target for dementia prevention.

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Area of Science:

  • Cardiovascular Health
  • Neurology
  • Gerontology

Background:

  • Arterial stiffness is linked to Alzheimer's disease and related dementias.
  • The impact of intensive blood pressure control on arterial stiffness and cognitive impairment is not fully understood.

Purpose of the Study:

  • To investigate the effect of intensive blood pressure control on arterial stiffness parameters.
  • To examine the association between arterial stiffness and cognitive impairment in the SPRINT trial.

Main Methods:

  • SPRINT trial compared intensive (SBP<120mmHg) vs. standard (SBP<140 mmHg) blood pressure control.
  • Arterial stiffness (T-PWV, S-PWV, LD-PWV) was measured at baseline and over 3 years.
  • Cognitive impairment (MCI/PD) was assessed over 10 years; time-to-event analysis was performed.

Main Results:

  • Higher baseline T-PWV and S-PWV were associated with increased cognitive impairment risk.
  • Intensive blood pressure control led to a decline in load-dependent stiffening (LD-PWV).
  • Declines in LD-PWV were linked to a 21% reduced risk of cognitive impairment.

Conclusions:

  • Arterial stiffness components are associated with cognitive impairment, independent of blood pressure control.
  • Arterial stiffness is an overlooked risk factor for cognitive impairment.
  • Targeting arterial stiffness may be a strategy for dementia prevention.