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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Sandhya Mangalore1

  • 1National Institute of Mental Health and Neurosciences, Bengaluru, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study shows amyloid positron emission tomography (PET) imaging is more sensitive than FDG-PET and clinical evaluation for diagnosing dementia in India. The radiotracer NAV4694 demonstrated feasibility in the Indian population.

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Area of Science:

  • Neurology
  • Radiology
  • Nuclear Medicine

Background:

  • Amyloid imaging is crucial for detecting amyloid plaques in dementia.
  • Multimodal imaging comparisons are essential for accurate diagnosis.
  • This study focuses on the Indian population, a region with limited amyloid imaging data.

Purpose of the Study:

  • To evaluate the efficacy of the radiotracer NAV4694 for amyloid imaging in an Indian population.
  • To compare the sensitivity of amyloid PET with FDG-PET and clinical evaluation.
  • To establish the feasibility of simultaneous MR-PET amyloid imaging in India.

Main Methods:

  • Twelve participants (53-75 years) underwent clinical assessment and MR-PET scans with 18F-NAV4694.
  • Standardized in-house radiolabeling of 18F-NAV4694 was performed.
  • Quantitative analysis included Standardized Uptake Value Ratio (SUVR) and Centiloid Scale (CL).

Main Results:

  • Amyloid PET imaging demonstrated higher sensitivity in diagnosing Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) compared to FDG-PET and clinical evaluation.
  • The ratio of AD:FTD changed from 5:7 to 7:5 post-amyloid PET imaging.
  • Simultaneous MR-PET acquisition provided precise depiction of structural, functional, and metabolic abnormalities.

Conclusions:

  • Simultaneous MR-PET amyloid imaging with NAV4694 is effective and feasible in the Indian population.
  • Amyloid PET imaging offers superior diagnostic accuracy over FDG-PET and clinical assessment.
  • Further correlation with other advanced imaging modalities like ASL and Bloodpool is warranted.