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Updated: Jan 7, 2026
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Protocol to investigate neurophysiological link between resting-state brain activity and clinical symptoms in
Yi-Han Yan1, Yi Zhang1, Taicheng Huang1
1Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and School of Psychology, Shanghai 200030, China.
Abstract:
The absence of reliable biomarkers impedes the objective diagnosis and monitoring of many psychiatric symptoms. Here, using cue-induced craving in methamphetamine use disorder as a case example, we present a protocol for linking neurophysiological characteristics to clinical symptoms through high-density electroencephalography (HD-EEG). We describe steps for HD-EEG data acquisition, signal preprocessing, source localization, and functional connectivity network construction. We then detail procedures for association analysis with clinical symptom scores. This protocol holds potential for application to diverse psychiatric conditions. For complete details on the use and execution of this protocol, please refer to Tian et al.1.
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