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Related Experiment Video

Updated: Jan 7, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
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Transfer of interferon beta in term placentae.

Eleanor Doman1, Angelos Evangelinos1, Lewis Renshall1

  • 1Maternal and Fetal Health Research Centre and Manchester Academic Health Sciences Centre, University of Manchester, UK.

Multiple Sclerosis and Related Disorders
|December 24, 2025
PubMed
Summary

Interferon beta (IFN-β) transfer across the term placenta is minimal, suggesting its safety for treating multiple sclerosis (MS) during pregnancy. This finding reassures patients and clinicians about using IFN-β medications in the third trimester.

Keywords:
Interferon betaMultiple sclerosisPlacental transferPregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Immunology

Background:

  • Multiple sclerosis (MS) relapse risk increases postpartum, necessitating pregnancy treatment considerations.
  • Disease-modifying therapies (DMTs) like interferon beta (IFN-β) may be considered during pregnancy.
  • Existing safety data for IFN-β in pregnancy primarily covers early gestation.

Purpose of the Study:

  • To investigate the transfer of IFN-β across the term placenta.
  • To provide laboratory evidence on IFN-β placental transfer for pregnant MS patients.

Main Methods:

  • Ex vivo dual perfusion of term placental tissue (n=3) over 6 hours.
  • IFN-β was added to the maternal circulation.
  • Fetal circulation was sampled to quantify IFN-β transfer.

Main Results:

  • Minimal transfer of IFN-β between maternal and fetal circulation was observed.
  • Maximum transfer was less than 0.03% of the maternal concentration across all experiments.

Conclusions:

  • The study supports considering IFN-β based MS medications during pregnancy.
  • Minimal term placental transfer of IFN-β offers reassurance for third-trimester use.