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Clinical Manifestations.

Federica Ribaldi1, Christian Chicherio2, Augusto J Mendes3

  • 1Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Geneva, Switzerland.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

A new taxonomy helps classify subjective cognitive decline (SCD) into subgroups based on psychological factors and comorbidities. This approach aids in identifying individuals at higher risk for Alzheimer's disease (AD) and guides personalized interventions.

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Area of Science:

  • Neurology
  • Gerontology
  • Psychiatry

Background:

  • Subjective cognitive decline (SCD) is an emerging risk factor for Alzheimer's disease (AD) and other dementias.
  • Standardized assessment and management of SCD are limited, despite increasing prevalence in memory clinics.
  • A novel taxonomy categorizes SCD into subgroups based on psychological factors, comorbidities, or no apparent cause.

Purpose of the Study:

  • To validate a proposed taxonomy for Subjective Cognitive Decline (SCD) in independent cohorts.
  • To assess the clinical applicability of the SCD taxonomy for risk stratification.
  • To guide personalized management strategies for individuals experiencing cognitive decline.

Main Methods:

  • The SCD taxonomy was initially tested on a small cohort and is now being applied to a larger retrospective cohort.
  • An automated algorithm was developed to classify individuals into SCD subgroups based on clinical data.
  • Validation involves comparing automated classification with expert judgment, followed by subgroup analysis and longitudinal cognitive trajectory assessment.

Main Results:

  • Preliminary findings indicate the taxonomy effectively stratifies individuals based on psychological factors and comorbidities.
  • Significant differences in demographics, clinical features, and cognitive trajectories were observed across SCD subgroups.
  • The subgroup with no apparent cause showed faster cognitive decline and an AD-like biomarker profile.

Conclusions:

  • The SCD taxonomy shows promise as a clinical tool for risk stratification and personalized interventions.
  • Validation in larger cohorts is crucial for integrating the taxonomy into routine clinical practice.
  • This approach addresses the growing need for tailored management of individuals with SCD.