Jove
Visualize
Contact Us

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural MRI and mild behavioral impairment as complementary predictors of conversion from amnestic MCI to Alzheimer's disease.

Neuroscience·2026
Same author

Stronger right-hemispheric involvement in language processing is associated with greater functional connectivity between the left-lateralized language-related network and the cingulo-opercular network.

Brain structure & function·2026
Same author

Phonetic clustering characteristics in verbal fluency: A potential marker for differentiating subjective cognitive decline from mild cognitive impairment.

Applied neuropsychology. Adult·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The Russian Rey Auditory Verbal Learning Test (RAVLT): version comparison and normative data for children aged 5-18 years.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence·2025
Same author

The left pars triangularis lesions impair semantic interference resolution regardless of competitor modality.

Cerebral cortex (New York, N.Y. : 1991)·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Clinical Manifestations.

Nikita Cherkasov1,2, Ekaterina Rodionova2, Arina Zvereva2

  • 1Mental Health Research Center, Moscow, Moskva, Russian Federation.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary

Qualitative language analysis in verbal fluency tasks can help distinguish between subjective cognitive decline (SCD) and mild cognitive impairment (MCI). These novel linguistic characteristics improve diagnostic accuracy for pre-dementia states.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Area of Science:

  • Neuroscience
  • Linguistics
  • Gerontology

Background:

  • Previous research indicates qualitative language features in verbal fluency tasks can differentiate neurodegenerative conditions like frontotemporal dementia.
  • Limited data exists on the association between qualitative verbal fluency parameters and pre-dementia stages, specifically subjective cognitive decline (SCD) and mild cognitive impairment (MCI).

Purpose of the Study:

  • To investigate the utility of qualitative linguistic characteristics derived from semantic verbal fluency (SVF) tasks in differentiating between individuals with SCD and MCI.
  • To assess whether incorporating these qualitative features enhances the diagnostic prediction of cognitive status and Montreal Cognitive Assessment (MoCA) scores compared to standard SVF scores alone.

Main Methods:

  • A Semantic Verbal Fluency (SVF) task was administered to 40 SCD patients and 51 MCI patients.
  • Computerized analysis extracted phonemic and semantic linguistic clusters, calculating qualitative features like number of switches and mean cluster size.
  • Linear mixed-effects models were used to compare diagnostic prediction based on standard SVF scores versus SVF scores augmented with qualitative linguistic features, controlling for age, sex, and education.

Main Results:

  • Significant differences were observed between SCD and MCI groups in SVF total scores and several cluster characteristics, including phonemic and semantic mean cluster sizes and semantic first cluster size.
  • A model incorporating qualitative linguistic features demonstrated superior prediction of MoCA scores and diagnosis compared to a base model using only the routine SVF task score.
  • ANOVA tests confirmed the enhanced predictive power of the full model (including qualitative features) for both cognitive assessment and diagnostic classification.

Conclusions:

  • Novel qualitative language characteristics derived from SVF tasks show promise as a tool for improving diagnostic algorithms in pre-dementia states.
  • Computerized analysis of these linguistic features can aid in better understanding the underlying language difficulties associated with SCD and MCI.
  • The integration of qualitative linguistic analysis represents a potential advancement in the early detection and characterization of cognitive decline.