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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations
Carlos Orellana1, Ixim Anibal Morales1, Jorge Ochoa2
1GBHI, San Francisco, CA, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Neuropsychiatric symptoms like depression and anxiety are early signs of Alzheimer's disease (AD). This study investigates their link to brain changes, aiming to improve dementia care.
Area of Science:
- Neurology
- Psychiatry
- Medical Imaging
Background:
- Neuropsychiatric symptoms (NPS), including depression and anxiety, are prevalent in early Alzheimer's disease (AD).
- These symptoms often precede noticeable cognitive decline, complicating diagnosis and care.
- Underlying mechanisms of NPS in AD, especially in underserved populations, require further investigation.
Purpose of the Study:
- To explore the relationship between neuropsychiatric symptoms and neuroimaging markers in individuals with early cognitive decline.
- To understand the biological underpinnings of early psychiatric manifestations in Alzheimer's disease.
Main Methods:
- Retrospective cohort study using electronic health records from REDGESAM.
- Inclusion of patients aged 50+ with mild cognitive impairment (MCI) or subjective cognitive decline (SCD).
- Analysis of standardized neuropsychiatric assessments, brain imaging data, and advanced statistical modeling.
Main Results:
- Anticipated identification of correlations between NPS and brain imaging markers like hippocampal volume and white matter integrity.
- Expected deeper understanding of how early psychiatric symptoms correspond with biological brain changes in AD.
Conclusions:
- Findings will inform targeted interventions for depression and anxiety in early AD.
- This research aims to enhance patient outcomes and contribute to global dementia care strategies.
- Leveraging robust data from REDGESAM for significant advancements in AD research.
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