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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Rifa Sanjida Punnota1, Paul Edison1,2

  • 1Imperial College London, London, Greater London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

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Novel global measures for Alzheimer's disease biomarkers like Tau, hypometabolism, and atrophy significantly predict cognition better than traditional methods. These global metrics offer improved quantification for clinical trials.

Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Research
  • Biomarker Quantification

Background:

  • Alzheimer's Disease (AD) involves β-Amyloid (Aβ) and Tau deposition, leading to cognitive decline.
  • Current region-of-interest (ROI) analysis for AD biomarkers has limitations, including potential false negatives.
  • Novel 'global' measures were developed to overcome ROI limitations in quantifying AD pathology.

Purpose of the Study:

  • To investigate the utility of novel 'global' measures for quantifying Aβ, Tau, glucose hypometabolism, and grey matter atrophy.
  • To compare the predictive performance of global measures against traditional ROI analysis for cognitive function in AD.
  • To assess the potential of global measures for future clinical trials in Alzheimer's Disease.

Main Methods:

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  • Analysis of 2596 scans (PET and MRI) from 743 participants across the AD spectrum.
  • Generation of Standardized Uptake Value Ratio (SUVR) and Voxel-Based Morphometry (VBM) images.
  • Calculation of 'global' measures (Global Cortical Tau Load, Aβ Load, Hypometabolism, GM Atrophy) via single-subject voxel-wise analysis and comparison to controls.

    • Main Results:

    • Global measures significantly predicted baseline cognition in participants.
    • Global Cortical Tau Load outperformed traditional ROI measures and was a strong predictor in Aβ-positive individuals.
    • Global Hypometabolism and Global GM Atrophy were superior predictors compared to Whole Brain ROI in MCI and AD participants.

    Conclusions:

    • Global measures for Tau, hypometabolism, and GM atrophy demonstrate superior cognitive prediction compared to traditional methods.
    • These global metrics show promise for adoption in future Alzheimer's Disease clinical trials.
    • Global Cortical Tau Load may be an optimal method for quantifying early Tau deposition in AD progression.