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Updated: Jan 24, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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Biomarkers.

Gemma Natalie Wright1, James Neil Dodds1, Rifa Sanjida Punnota2

  • 1Imperial College London, London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 22, 2026
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Summary
This summary is machine-generated.

A 10.5% discordance exists between cerebrospinal fluid (CSF) amyloid and PET imaging results in Alzheimer's Disease (AD) patients. Discordant individuals showed lower levels of tau pathology, suggesting other neurodegenerative processes may be involved.

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Area of Science:

  • Neurology
  • Biomarker Research
  • Alzheimer's Disease Diagnostics

Background:

  • Alzheimer's Disease (AD) research increasingly focuses on cerebrospinal fluid (CSF) biomarkers.
  • CSF and PET imaging are used to determine amyloid status in AD, though discordant results can occur.
  • The proportion and clinical implications of discordant amyloid status in AD remain unclear.

Purpose of the Study:

  • To investigate the discordance rate between CSF Aβ42:40 and PET amyloid status in Alzheimer's Disease.
  • To evaluate if discordant amyloid status is associated with different levels of tau aggregation and clinical characteristics.

Main Methods:

  • Utilized data from 313 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
  • Calculated the cutoff for CSF Aβ42:40 using the Youden Index from ROC curve analysis (cutoff = 0.057).
  • Performed t-tests to compare clinical and tau pathology differences between concordant and discordant groups.

Main Results:

  • A discordance rate of 10.5% (33 out of 313 participants) was observed between CSF Aβ42:40 and PET amyloid status.
  • Discordant individuals exhibited significantly lower levels of phosphorylated tau 181 (pTau181) and total Tau compared to concordant individuals.
  • Statistical significance was found for pTau181 (t(71.2)=-3.166, p=.002) and Tau (t(53.9)=-2.046, p=.046) differences.

Conclusions:

  • The differing tau levels in discordant groups suggest other pathological processes may contribute to neurodegeneration in these Alzheimer's Disease subjects.
  • The observed 10% discordance highlights the need for detailed evaluation of these individuals before their inclusion in intervention studies.
  • Further research is warranted to understand the implications of discordant amyloid status in AD progression and treatment.