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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Chiara Maria Righini1, Larissa Estessi de Souza1, Jean Marques Brizola1

  • 1University of São Paulo Medical School, São Paulo, São Paulo, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Physical exercise combined with cannabidiol (CBD) shows neuroprotective effects in a Down Syndrome (DS) mouse model. This combination enhanced brain metabolism, suggesting a potential strategy to delay Alzheimer's disease (AD) development in DS individuals.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Down Syndrome (DS) is linked to early-onset Alzheimer's disease (AD) due to increased expression of AD-related genes, causing neuroinflammation and cell death.
  • The growing lifespan of the DS population necessitates strategies to delay AD progression and enhance quality of life.
  • Physical exercise and cannabidiol (CBD) are known for their neuroprotective properties.

Purpose of the Study:

  • To investigate the effects of physical exercise and CBD, individually and in combination, on a mouse model of Down Syndrome (DS).
  • To assess neuroinflammation and brain metabolism using positron emission tomography (PET) in DS mice under different treatment conditions.

Main Methods:

  • Ts65Dn trisomic mice were divided into four groups: control, exercise, CBD, and exercise+CBD.
  • Exercise involved treadmill activity three times weekly from 2 to 8 months of age.
  • CBD was administered intraperitoneally (20 mg/kg) for 30 days starting at 7 months of age.
  • PET imaging ([11C]PK11195 and [18F]FDG) was used to evaluate neuroinflammation and brain metabolism at 4 and 8 months of age.

Main Results:

  • At 4 months, the exercise+CBD group showed significantly higher [11C]PK11195 uptake (neuroinflammation marker) in the whole brain (WB) and hippocampus compared to other groups.
  • At 8 months, both CBD and exercise+CBD groups exhibited increased [11C]PK11195 uptake compared to control and exercise groups.
  • The exercise+CBD group demonstrated increased [18F]FDG uptake (brain metabolism) from 4 to 8 months in both WB and hippocampus.

Conclusions:

  • CBD treatment alone induced a notable glial response, which was modulated when combined with physical exercise.
  • The combination of exercise and CBD enhanced brain metabolism, suggesting a potential neuroprotective mechanism against AD development in DS.
  • This combined approach may offer a promising strategy for improving brain health in individuals with Down Syndrome.