Biomarkers

Area of Science:

• Neuroscience
• Neurology
• Biomarkers

Background:

• Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are complex neurodegenerative disorders.
• The role of Alzheimer's disease (AD) co-pathology in CBS and PSP is not fully understood.
• Existing associations between clinical features and AD neuropathology in these syndromes lack specificity.

Purpose of the Study:

• To investigate how Alzheimer's disease (AD)-related biomarkers influence clinical presentation, brain structure, and functional connectivity in CBS and PSP patients.
• To explore the impact of AD co-pathology on the neuroimaging and clinical manifestations of CBS and PSP.
• To enhance diagnostic accuracy and inform personalized management strategies for CBS and PSP.

Main Methods:

• Utilized neuroimaging techniques, including MRI and fMRI, to detect patterns of brain atrophy and functional disconnection.
• Assessed fluid biomarker positivity for Alzheimer's disease.
• Correlated biomarker status with distinct motor and cognitive features.

Main Results:

• AD fluid biomarker positivity is linked to specific patterns of brain atrophy.
• Alzheimer's disease biomarkers are associated with distinct functional disconnection patterns.
• Biomarker status correlates with differences in motor and cognitive features in CBS and PSP patients.

Conclusions:

• The presence of AD co-pathology significantly shapes the clinical and neuroimaging presentation of CBS and PSP.
• Biomarker-based stratification of patients can improve diagnostic accuracy.
• Understanding AD co-pathology is essential for developing personalized treatment approaches for these syndromes.