Anti-inflammatory triterpenoids from dammar resin of Vatica mangachapoi
Rui-Jie Feng1, De-Li Chen2, Jian-He Wei1
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China.
Abstract:
Five previously undescribed triterpenoids (1-5), and four triterpenoids (6-9) which had been synthesized previously but had not been isolated from a natural source, along with twenty-three known triterpenoids (10-32) were isolated from the methanol extract of dammar resin of Vatica mangachapoi. HRESIMS, NMR, UV, and ECD spectroscopy were employed to determine the structures of these triterpenoids. Compounds 2, 6, 22, and 29 significantly reduced LPS-induced TNF-α levels in RAW264.7 cells, while compounds 3, 13, 16, and 17 reduced IL-6 levels at a concentration of 10 μM. These results suggest that these compounds exhibit potential anti-inflammatory activity.
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