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Related Experiment Video

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Nadia A Bossa1, Eliane C Miotto1, Geraldo Busatto Filho2

  • 1University of São Paulo, São Paulo, São Paulo, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Image-based cognitive training (CT) improved memory and strategy use in patients with mild cognitive impairment (MCI) and healthy controls. The Aβ- MCI group showed the most significant gains in memory recall after training.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Alzheimer's disease biomarker (Aβ) status influences cognitive function in mild cognitive impairment (MCI).
  • Image-based unimodal cognitive training (CT) is a potential intervention for cognitive decline.

Purpose of the Study:

  • To evaluate the efficacy of image-based CT on cognitive function in Aβ+ MCI, Aβ- MCI, and healthy controls (HC).
  • To compare the impact of CT across different cognitive domains and participant groups.

Main Methods:

  • Fifty-five older adults (Aβ+ MCI, Aβ- MCI, HC) underwent neuropsychological assessments pre- and post-CT.
  • Evaluated subjective memory complaints, strategy use, and objective memory performance (Logical Memory, RAVLT, Generalization Tasks).
  • Statistical analyses included ANOVA and Kruskal-Wallis tests with post hoc comparisons.

Main Results:

  • Cognitive training significantly reduced memory complaints and increased strategy use in both MCI groups.
  • All groups showed improvements in immediate memory recall, with Aβ- MCI benefiting most relative to HC.
  • Delayed memory recall and generalization task performance improved in all groups, but significant differences between MCI and HC persisted.

Conclusions:

  • Image-based CT enhances memory, strategy use, and generalization capabilities in individuals with MCI and HC.
  • The Aβ- MCI group demonstrated the most substantial improvements in immediate and delayed memory recall post-intervention.