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Clinical Manifestations.

Jorge Alcina1, Nikole A Bonillas Félix1, Randy Medrano1

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Mild Behavioral Impairment (MBI) symptoms, specifically decreased motivation, are linked to functional difficulties in older Latinos. Early assessment of these neuropsychiatric symptoms is crucial for this population.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Latinos face a higher risk of Alzheimer's Disease and Related Dementias (ADRD).
  • Mild Behavioral Impairment (MBI) involves new neuropsychiatric symptoms in adults over 50, linked to cognitive decline and functional burden.
  • The MBI-cognition relationship is understudied in Latino populations.

Purpose of the Study:

  • To investigate the association between MBI severity and functional impairment in cognitively unimpaired, community-dwelling older Latinos.
  • To explore the impact of specific MBI domains (Interest/Motivation/Drive and Mood/Anxiety) on daily functioning.

Main Methods:

  • 126 cognitively unimpaired older Latinos (≥55 years) from the Boston Latino Aging Study (BLAST) participated.
  • Mild Behavioral Impairment Checklist (MBI-C) self-reports and Functional Activities Questionnaire (FAQ) informant-reports were used.
  • Regression models analyzed the effect of MBI-C domains on FAQ scores, controlling for age, sex, education, and global cognition (MMSE).

Main Results:

  • Higher scores in the MBI-C Interest/Motivation/Drive (IMD) domain were significantly associated with greater functional impairment (FAQ scores).
  • MBI-C Mood/Anxiety (MA) domain scores did not show a significant association with functional impairment.
  • A minority (20%) reported clinically significant depressive symptoms.

Conclusions:

  • Decreased motivation, a component of MBI, is associated with increased functional burden in daily living among cognitively unimpaired older Latinos.
  • Neuropsychiatric symptoms, particularly those related to motivation, warrant assessment and management in older Latino adults.
  • Further longitudinal research with larger, diverse samples is needed to understand these functional effects in minoritized groups.