Related Experiment Video
Updated: Jan 7, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
859
Comprehensive Obesity Medicine Management in Metabolic and Bariatric Surgery (COMMMBS) Algorithm: An Evidenced Based
Charles Campbell1, Pavaani Peddi1, Ann Rogers2
1Department of Surgery, University of South Florida, Tampa, United States.
Obesity Surgery
|December 26, 2025
Summary
Obesity management medications (OMMs) can enhance weight loss alongside metabolic and bariatric surgery (MBS). This review aims to create an algorithm guiding the use of OMMs before or after MBS for better patient outcomes.
Area of Science:
- Metabolic and Bariatric Surgery
- Pharmacotherapy for Obesity
Background:
- Metabolic and bariatric surgery (MBS) is effective for weight loss.
- Obesity management medications (OMMs) offer additional benefits for many patients.
- Optimal timing for integrating OMMs with MBS is currently unclear.
Purpose of the Study:
- To review and grade existing literature on OMMs and MBS.
- To develop a clinical algorithm for using OMMs in the neoadjuvant and adjuvant settings with MBS.
Main Methods:
- Systematic literature review.
- Grading of current evidence.
- Algorithm formulation based on reviewed data.
Main Results:
- Evidence synthesis on OMM use alongside MBS.
- Identification of optimal timing for OMM initiation (pre- or post-surgery).
- Development of a practical physician-guided algorithm.
Conclusions:
- An evidence-based algorithm can guide the judicious use of OMMs with MBS.
- Integrating OMMs strategically can optimize weight management and patient care.
- Further research may refine OMM and MBS combination protocols.
Related Concept Videos
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
211
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
211
01:21Drug Dosing: Obese Patients
189
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
189
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
149
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
149
01:15Diabetes: Management and Pharmacotherapy
835
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
835
01:21Inflammatory Bowel Disease V: Surgical Management
420
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
420