N6-methyladenosine (m6A) RNA methylation: a potential clinical therapeutic target in cardiocerebrovascular diseases

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Updated: Jan 7, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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Hao Zhang1, Yilin Wu2, Rui Zhao3

  • 1Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China; Guangzhou Huateng Bioscience Corporation, Guangzhou 510530, China.

Pharmacology & Therapeutics
|December 26, 2025
PubMed

Insights

N6-methyladenosine (m6A) modification is crucial in regulating gene expression and shows potential as a biomarker for diagnosing and treating cardiocerebrovascular diseases (CCD). Further research into m6A offers new perspectives for early CCD diagnosis and clinical intervention.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Cardiocerebrovascular disease (CCD) poses a significant threat to human health, characterized by high incidence, disability, and mortality.
  • Current treatment options for CCD are limited, highlighting the need for novel diagnostic and therapeutic strategies.
  • Epigenetic modifications, particularly N6-methyladenosine (m6A) RNA methylation, are emerging as critical regulators in various biological processes.

Purpose of the Study:

  • To review the function and mechanism of m6A modification in the context of cardiocerebrovascular disease (CCD).
  • To explore the potential of m6A as a diagnostic and prognostic biomarker for CCD.
  • To present a fresh perspective on early diagnosis and clinical treatment of CCD based on m6A modification.

Main Methods:

  • Literature review focusing on the role of m6A in gene expression regulation.
  • Analysis of studies investigating m6A modification in relation to cardiocerebrovascular disease.
  • Synthesis of current knowledge on m6A methyltransferases, demethylases, and reader proteins.

Main Results:

  • m6A modification is a prevalent internal modification in eukaryotic messenger RNA (mRNA) and plays a vital role in epigenetic regulation.
  • m6A influences gene expression at epigenetic, transcriptional, and post-transcriptional levels, impacting processes like tumor development and stem cell differentiation.
  • m6A modification has been identified as a potential biomarker for the diagnosis and prognosis of cardiocerebrovascular disease.

Conclusions:

  • N6-methyladenosine (m6A) modification is integral to numerous bioprocesses and significantly impacts cardiocerebrovascular disease (CCD) pathogenesis.
  • m6A modification holds promise as a valuable biomarker for early diagnosis and predicting the prognosis of CCD.
  • Understanding the intricate role of m6A in CCD can pave the way for developing innovative therapeutic strategies and improving patient outcomes.

Keywords:
Cardiocerebrovascular diseasesDiagnosis and treatmentN6-methyladenosine

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