[Research and application progress of organoids in head and neck squamous cell carcinoma]

Organoid is an emerging preclinical model for tumor research, which can effectively maintain genetic stability and recapitulate the heterogeneity of parental tumors. Tumor organoid models are widely used in the research on the mechanisms of tumorigenesis and progression, prediction of therapeutic response, drug screening and other related fields. This review summarizes the characteristics of organoids, the application scope and application value of tumor organoids in the field of head and neck cancers, aiming to provide a reference for the realization of precision medicine in head and neck cancers and the development of basic scientific research in the future.