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Related Experiment Video

Updated: Jan 7, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Reparative Effects of 3D-Printed PLGA/CHA/nmZnO Composite Scaffolds on Inflammatory Periodontal Bone Defects in Rats.

Chong-Yan Xu1,2, Yuan Zhao2, Ji-Fan Zhan1,2

  • 1Postgraduate Research Institute, Kunming Medical University, Kunming, China.

Journal of Biomedical Materials Research. Part A
|December 29, 2025
PubMed
Summary

This study developed PLGA/CHA/nmZnO bone scaffolds for periodontitis. The optimal 30% scaffold demonstrated significant bone regeneration and immune regulation, outperforming Bio-Oss.

Keywords:
PLGA/CHA/nmZnO composite scaffoldbioinformatics analysisbone regenerationperiodontitis

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Periodontology

Background:

  • Periodontitis leads to significant bone loss, necessitating effective bone regeneration strategies.
  • Current bone graft materials have limitations in osteogenesis and immunomodulation.

Purpose of the Study:

  • To develop and optimize PLGA/CHA/nmZnO composite scaffolds for periodontal bone regeneration.
  • To evaluate the osteogenic potential and immunomodulatory effects of varying CHA/nmZnO content.

Main Methods:

  • 3D melt extrusion molding was used to fabricate PLGA/CHA/nmZnO scaffolds with varying filler concentrations.
  • Physicochemical properties, biocompatibility, and in vitro osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were assessed.
  • In vivo osteogenic effects were evaluated in a rat periodontitis bone defect model, with comparisons to Bio-Oss.

Main Results:

  • Scaffolds exhibited interconnected pores and suitable mechanical properties.
  • Composite scaffolds with 25-35% CHA/nmZnO significantly promoted BMSC proliferation and osteogenic differentiation.
  • The 30% scaffold demonstrated superior bone regeneration in vivo, increasing BV/TV, BS/TV, and collagen formation, while inhibiting inflammation-related factors (TLR2, TLR7, IL-1β).

Conclusions:

  • The optimal PLGA/CHA/nmZnO scaffold (30% content) exhibits excellent osteogenic induction and immune regulation for periodontal bone regeneration.
  • This optimized scaffold holds promise as a novel material for treating periodontal defects, surpassing conventional bone grafts.