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Integrative Regulatory Networks of MicroRNA-483: Unveiling Its Systematic Role in Human Diseases and Clinical

Jiatong Xu1,2, Shupeng Luxu1,2, Hsi-Yuan Huang1,2,3

  • 1School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.

Biomolecules
|December 30, 2025
PubMed

Insights

MicroRNA-483 (miR-483) has dual roles in disease, promoting cancer but protecting other tissues. Its context-dependent activity is driven by specific signaling pathways, making it a potential biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNA-483 (miR-483) is implicated in various human diseases, including cancer, cardiopulmonary, metabolic, immune, neurological, and musculoskeletal conditions.
  • Understanding the regulatory network of miR-483 is crucial for deciphering its multifaceted roles in human pathologies.

Purpose of the Study:

  • To construct a comprehensive regulatory network for miR-483 by integrating data from 146 studies.
  • To elucidate the molecular mechanisms underlying the context-dependent activity of miR-483 across different disease categories.

Main Methods:

  • Integration of experimentally validated interactions involving transcription factors, long non-coding RNAs, circular RNAs, and messenger RNA targets.
  • Network analysis to identify core signaling pathways (TGF-β and MAPK) modulating miR-483 activity.

Main Results:

  • miR-483 promotes tumorigenesis by inhibiting tumor-suppressive checkpoints.
  • miR-483 exhibits protective effects in cardiopulmonary, metabolic, and neurological tissues against pathological injury.
  • Tissue-specific modulation of TGF-β and MAPK signaling pathways dictates the dual function of miR-483.

Conclusions:

  • The context-dependent activity of miR-483 is determined by its regulatory circuits and modulation of key signaling hubs.
  • miR-483 serves as a potential diagnostic biomarker and therapeutic target, with its function contingent on the cellular context.
Keywords:
biomarkerceRNAmiRNA-483regulatory networktherapeutic targettranscription factor

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