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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Still the same tune: unchanged antibiotic-associated adverse event rates support the need for outpatient

Ganga Moorthy1,2, Matthew P Kronman3,4

  • 1Department of Pediatrics, Duke School of Medicine, Box 3352 DUMC, Durham, NC 27710.

Journal of the Pediatric Infectious Diseases Society
|December 30, 2025
PubMed

Insights

Pediatric antibiotic-associated adverse events saw an overall annual decrease from 2019-2023. However, 2023 events returned to historical levels, highlighting the need for continued antimicrobial stewardship.

Area of Science:

  • Pediatric Health
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic-associated adverse events (AAEs) are a significant concern in pediatric populations.
  • The period 2019-2023 encompassed the COVID-19 pandemic, a major disruptor of healthcare patterns.

Purpose of the Study:

  • To analyze trends in pediatric AAEs from 2019 to 2023.
  • To assess the impact of the COVID-19 pandemic on these trends.
  • To evaluate the ongoing need for outpatient antimicrobial stewardship.

Main Methods:

  • Retrospective analysis of pediatric AAE data from 2019-2023.
  • Statistical comparison of annual AAE rates.
  • Evaluation of pandemic-related influences on AAE occurrence.

Main Results:

  • A decrease in the overall average annual number of pediatric AAEs was observed during the study period.
  • However, AAEs in 2023 alone were comparable to pre-pandemic historical numbers.
  • The COVID-19 pandemic influenced the observed trends in pediatric AAEs.

Conclusions:

  • Despite an overall decrease, pediatric AAEs in 2023 indicate a return to baseline levels.
  • Sustained outpatient antimicrobial stewardship programs are crucial for managing pediatric AAEs.
  • Pandemic-era changes necessitate continued vigilance in antimicrobial use.
Abstract

No abstract available in PubMed .

Keywords:
Pediatricsadverse eventsambulatoryantibioticsemergency department

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