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Updated: Jan 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Organophotocatalytic Radical Cascade Cyclization To Access 2-Trifluoromethylthiolated Quinoline Derivatives
Congjun Zhu1, Zilong Wang1, Yangyang Shen1
1School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China.
Abstract:
The quinoline skeleton is commonly found in active molecules, making its synthesis a major focus of the ongoing research. This study presents a photoinduced strategy for synthesizing 2-trifluoromethylthiolated quinoline derivatives. This one-pot process involves a radical cascade cyclization between 1-isocyano-2-vinylbenzenes and Phth-SCF3. Notably, the transformation proceeds in the absence of transition metals or oxidants and shows excellent chemoselectivity and broad functional group compatibility.
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