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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
BIOMARKERS OF RADIATIONINDUCED GENOMIC INSTABILITY IN SOMATIC CELLS
L V Neumerzhytska1, D A Kurinnyi1, V V Talko1
1State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of theNational Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
None:
The review highlights current ideas about the mechanisms of radiationinduced genome instability formation.Based on the results of a search in the abstract medical and biological database PubMed/MEDLINE, Google Scholarand a manual search of relevant information sources, data on the use of some cytogenetic and molecular geneticmethods as biomarkers of the effects of lowdose acute and prolonged radiation are analyzed and summarized. Theeffectiveness of the use of natural radioprotectors under various radiation conditions (emergency, professional,radiotherapy, etc.) is considered. The search results confirm the feasibility of studying the radiationinduced effectat the cytogenetic, genomic and epigenomic levels, which will contribute to solving an important problem in radiobiology, radiation genetics and radiation protection to improve methods for assessing, predicting and preventing thenegative effects of radiation on human health.
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