Related Experiment Video
Updated: Jan 7, 2026

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
Published on: March 5, 2019
Intervention Using Low-Na/K Seasonings and Dairy at Japanese Company Cafeterias as a Practical Approach to Decrease
Nagako Okuda1, Aya Higashiyama2, Kozo Tanno3
1Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.
None:
Background/Objectives: Reducing sodium (Na) and increasing potassium (K) intake are important for lowering blood pressure (BP). Practical measures to decrease the dietary Na/K ratio are needed. A crossover design intervention study serving lunches prepared using K-enriched (low-Na/K) seasonings and dairy at an employee cafeteria was conducted. Methods: Participants consumed lunches containing low-Na/K seasonings and dairy as intervention meals and regular lunches as control meals for four weeks each, and we examined the changes in BP and urinary Na/K ratios. The Na and K contents of the meals were also measured. Results: A total of 166 employees (17.5% of whom were hypertensive, while 42.2% were women; mean age of 44.3 years) who regularly use the cafeteria completed the whole survey. The intervention meals contained less Na (66.4 vs. 74.2 mmol/serving) and more K (15.1 vs. 9.9 mmol/serving) than the control meals, and the average Na/K ratio was significantly lower (4.6 vs. 8.2, p < 0.001). The average urinary Na/K ratio was significantly lower in the intervention period than in the control (3.69 vs. 4.10, p = 0.008), but there was no difference in the average BP. Participants rated both the intervention and the control meals to be similarly good; 69.5% and 73.7% reported that the taste was fine, respectively, with no significant difference. Conclusions: Employing low-Na/K seasonings and habitual dairy consumption at lunchtime were effective in reducing urinary Na/K in a healthy working population. This may be a practical measure for sustainably decreasing dietary Na/K and controlling age-related increases in BP. UMIN-CTR registration: UMIN000050876.
Related Concept Videos
Antihypertensive Drugs: Potassium-Sparing Diuretics
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Hypertension IV: Drug Therapy and Lifestyle Modifications
Chronic Kidney Disease III: Interprofessional Care
Antihypertensive Drugs: Action of Diuretics
Nephrotic Syndrome III : Nursing Management

